Disease-gene association network
Dataset information
This is a dataset of associations between diseases and human genes.
| Dataset statistics | |
|---|---|
| Nodes | 23484 |
| Disease nodes | 5663 |
| Gene nodes | 17821 |
| Edges | 15509618 |
| Nodes in largest SCC | 23482 |
| Fraction of nodes in largest SCC | 1.000000 |
| Edges in largest SCC | 15509617 |
| Fraction of edges in largest SCC | 1.000000 |
| Diameter (longest shortest path) | 5 |
| 90-percentile effective diameter | 2.825574 |
The information is based on curated biomedical knowledge databases. In the knowledge databases, gene-disease associations are extracted from scientific publications by biocurators or derived from associations, which are experimentally documented in biological wet laboratories. Associations can also be established via, for example, chemical-gene interactions (e.g., gene A is associated with disease B because gene A has a curated interaction with chemical C, and chemical C has a curated association with disease B).
References
- The Comparative Toxicogenomics Database: update 2017. Davis, Allan Peter, et al. Nucleic Acids Research. 2016.
- OMIM.org: Online Mendelian Inheritance in Man, an online catalog of human genes and genetic disorders. Amberger, Joanna S., et al. Nucleic Acids Research. 2014.
- MINER: Gigascale multimodal biological network. Stanford SNAP Group. GitHub Repository. 2017.
Files
| File | Size | Description |
|---|---|---|
| DG-Miner_miner-disease-gene.tsv.gz | 817MB | Disease-gene association network (edgelist) |