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Tissue-specific protein-protein interaction network

Dataset information

This is a collection of physical protein-protein interaction networks for a large number of human tissues. Nodes represent human proteins and edges represent tissue-specific physical interactions between proteins.

Dataset statistics
Nodes 4510
Edges 70338
Nodes in largest SCC 4488
Fraction of nodes in largest SCC 1.000000
Edges in largest SCC 70316
Fraction of edges in largest SCC 0.999687
Average clustering coefficient 0.293465
Number of triangles 6698541
Fraction of closed triangles 0.045152
Diameter (longest shortest path) 6
90-percentile effective diameter 3.324356
Average tissues per edge 52.127769
Median tissues per edge 42
Standard deviation of tissues per edge 43.543761

The information is based on physical protein-protein interactions supported by experimental evidence. Interactions based on gene expression and evolutionary data are not considered. Tissue-specific networks are constructed based on a global (i.e., tissue-nonspecific) network. Given a human tissue, every interaction in the global network is labeled as specifically co-expressed in that tissue. An interaction is specifically co-expressed if either both proteins are specific to that tissue or one protein is tissue-specific and the other is ubiquitous. Finally, a protein-protein interaction network specific to the tissue is a subnetwork of the global network, induced by specifically co-expressed interactions.



File Size Description
PPT-Ohmnet_tissues-combined.edgelist.gz 712KB Tissue-specific protein-protein interaction network (edgelist)
PPT-Ohmnet_tissues-data.txt.gz 712KB Network statistics for different tissues