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S. cerevisiae transcriptional regulation network

Dataset information

This is a transcriptional regulation network for S. cerevisiae, a yeast. In the network, each node is an operon (a group of genes in a mRNA molecule), and a directed edge from operon i to operon j means that i is regulated by a transcriptional factor encoded by j. Furthermore, edges are signed to represent activation and repression. Coherent feedforward loops (FFLs) are a particular signed motif formed between three nodes, and such motifs are known to have particular functional roles. We include a list of coherent FFLs for this dataset along with their functional roles.

Dataset statistics
Nodes 690
Edges 1094
Nodes in largest WCC 664 (0.962)
Edges in largest WCC 1078 (0.985)
Nodes in largest SCC 3 (0.004)
Edges in largest SCC 5 (0.005)
Average clustering coefficient 0.0470
Number of triangles 72
Fraction of closed triangles 0.005467
Diameter (longest shortest path) 15
90-percentile effective diameter 7

Source (citation)


Files

File Description
S-cerevisiae.txt.gz Directed transcriptional regulation network
S-cerevisiae-names.csv.gz Names of operons
S-cerevisiae-coherent-FFLs.csv.gz Coherent feedforward loops and functionality