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Drug-target interaction network

Dataset information

This is a drug-target interaction network that contains information on which genes (i.e., proteins encoded by genes) are targeted by drugs that are on the U.S. market. Drug targets are molecules that play a critical role in the transport, delivery or activation of the drug. Drug target information is widely used to facilitate computational drug target discovery, drug design, drug docking or screening, drug metabolism prediction, drug interaction prediction, and general pharmaceutical research.

Dataset statistics
Nodes 3932
Drug nodes 284
Gene nodes 3648
Edges 18690
Nodes in largest SCC 3891
Fraction of nodes in largest SCC 1.000000
Edges in largest SCC 18660
Fraction of edges in largest SCC 0.998395
Diameter (longest shortest path) 9
90-percentile effective diameter 3.987420

This dataset considers only interactions between small chemicals (i.e., drugs) and target proteins that had been experimentally verified by biological experiments or formal pharmacological studies.



File Size Description
ChG-TargetDecagon_targets.csv.gz 361KB Drug-target protein associations (drugs are given by STITCH chemical IDs and proteins are given by NCBI Entrez Gene IDs)