{ "cells": [ { "cell_type": "markdown", "metadata": { "collapsed": true }, "source": [ "# Embedding the Human Disease Network\n", "\n", "*(This demo is a part of [Deep Learning for Network Biology](http://snap.stanford.edu/deepnetbio-ismb/) tutorial.)*" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "Human disease network is a network, in which nodes represent diseases and two diseases are connected to each other if they share at least one gene in which mutations are associated with both diseases.\n", "\n", "The network is described in Goh et al., [The Human Disease Network](http://www.pnas.org/content/104/21/8685), PNAS 2007." ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "The figure below show the human disease network. \n", "\n", "Although the layout of the network was generated independently of any knowledge of disease classes, the resulting network is naturally and visibly clustered according to major disease classes (e.g., bone, cancer, cardiovascular, skeletal, or metabolic diseases; each disease class is represented by a different color). The size of a node is proportional to the number of genes participating in the corresponding disease." ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "